Endometriosis · US
Endometriosis clinical trials in the US (2026)
33 endometriosis trials that are recruiting or about to recruit list at least one site in the US: 33 from the US registry (ClinicalTrials.gov) and 0 from the EU registry (CTIS). 7 are industry-sponsored.
By phase
Phase 4: 3, Phase 3: 3, Phase 2: 2, Phase 1/2: 1, Phase 1: 1, Early Phase 1: 1, N/A (non-drug): 11, Observational: 11
Lead sponsors
Washington University School of Medicine (3) · Milton S. Hershey Medical Center (2) · Mayo Clinic (2) · Samphire Group, Inc. (2) · Sumitomo Pharma Switzerland GmbH (2) · Kevin Hellman (1)
Open endometriosis trials with a site in the US
Newest registry update first. Every ID links to the official record. "est." marks the sponsor's estimated date. A trial registered in both systems may appear twice.
| ID | Title | Lead sponsor | Phase | Status | Primary completion | Enrolment | Site countries |
|---|---|---|---|---|---|---|---|
| NCT06559852 ClinicalTrials.gov | The Impact of Yoga on Endometriosis-Related Pain | Milton S. Hershey Medical Center | N/A (non-drug) | Recruiting | 30 Mar 2027 (est.) | 30 | United States |
| NCT06141720 ClinicalTrials.gov | Feasibility of a Mindfulness Intervention for Endometriosis Surgery | Milton S. Hershey Medical Center | N/A (non-drug) | Recruiting | 30 Jun 2027 (est.) | 20 | United States |
| NCT07508358 ClinicalTrials.gov | Vaginal Sildenafil for Primary Dysmenorrhea | Kevin Hellman | Phase 1 | Not yet recruiting | Jun 2027 (est.) | 10 | United States |
| NCT07810218 ClinicalTrials.gov | Personalized Exercise Recommendations for Chronic Pelvic Pain Using Reinforcement Learning | Icahn School of Medicine at Mount Sinai | N/A (non-drug) | Recruiting | Aug 2027 (est.) | 45 | United States |
| NCT07795125 ClinicalTrials.gov | Rimegepant For Endometriosis Pain | Mayo Clinic | Phase 2 | Not yet recruiting | 30 Mar 2031 (est.) | 132 | United States |
| NCT04567771 ClinicalTrials.gov | Comparison of Proton or Intensity Modulated Radiation Therapy After Surgery for Endometrial or Cervical Cancer | Mayo Clinic | N/A (non-drug) | Recruiting | 1 Apr 2029 (est.) | 121 | United States |
| NCT07420114 ClinicalTrials.gov | Outpatient Visits Versus Telehealth for Postoperative Care After Minimally Invasive Gynecologic Surgery | University of Chicago | Observational | Recruiting | Oct 2026 (est.) | 100 | United States |
| NCT06776289 ClinicalTrials.gov | Endodontic Microsurgery | Mark Schachman | Phase 4 | Not yet recruiting | Feb 2027 (est.) | 20 | United States |
| NCT05069740 ClinicalTrials.gov | Endometriosis and Microvascular Dysfunction: Role of Inflammation | Penn State University | Early Phase 1 | Recruiting | 31 Dec 2026 (est.) | 24 | United States |
| NCT07728695 ClinicalTrials.gov | Assessing the Mechanisms and Impact of a Novel Cannabinoid Product for Gynecologic Pain | Staci Gruber, Ph.D. | Phase 1/2 | Recruiting | Jan 2029 (est.) | 60 | United States |
| NCT06785129 ClinicalTrials.gov | Endometriosis and Migraine | Washington University School of Medicine | Observational | Recruiting | 1 Jan 2028 (est.) | 120 | United States |
| NCT06101303 ClinicalTrials.gov | Endometriosis Pain | Washington University School of Medicine | Observational | Recruiting | 1 Sep 2028 (est.) | 120 | United States |
| NCT07679074 ClinicalTrials.gov | CREST: Samphire Guided Care Program on Wellbeing, Work Productivity, and Quality of Life | Samphire Group, Inc. | Observational | Recruiting | 1 Jan 2027 (est.) | 50 | United States |
| NCT07664956 ClinicalTrials.gov | Cyclobenzaprine for Postoperative Pain in Minimally Invasive Hysterectomy | Christiana Care Health Services | Phase 4 | Not yet recruiting | 1 Sep 2026 (est.) | 36 | United States |
| NCT06439524 ClinicalTrials.gov | The Effect of Medical Management Following Excisional Surgery for Endometriosis: A Randomized Controlled Trial | Main Line Health | Phase 3 | Recruiting | 30 Jun 2028 (est.) | 110 | United States |
| NCT05245695 ClinicalTrials.gov | Deep Neural Network Stratification for Use Detecting Endometriosis in Women Affected by Chronic Pelvic Pain (EndoCheck) | Aspira Women's Health | Observational | Recruiting | 30 Jun 2026 (est.) | 1,200 | United States |
| NCT07568834 ClinicalTrials.gov | Impact of Pelvic Pain Podcast | Vanderbilt University Medical Center | N/A (non-drug) | Recruiting | 1 Aug 2027 (est.) | 100 | United States |
| NCT06671639 ClinicalTrials.gov | Stanford Program to Accelerate Robotic Children's Surgery | Stanford University | N/A (non-drug) | Recruiting | 28 Feb 2027 (est.) | 250 | United States |
| NCT07090096 ClinicalTrials.gov | A Randomized Controlled Trial of a Nutritional Intervention for Endometriosis | University of California, San Diego | N/A (non-drug) | Recruiting | 1 Oct 2028 (est.) | 120 | United States |
| NCT06847685 ClinicalTrials.gov | Mechanisms of Uterine Fluid Absorption During Early Pregnancy ( ELF Study) | Johns Hopkins University | Observational | Recruiting | 1 Feb 2029 (est.) | 140 | United States |
| NCT07100782 ClinicalTrials.gov | Estradiol-mediated Inflammation and Central Sensitization in the Pathophysiology of Endometriosis-associated Pelvic Pain | University of Michigan | Phase 3 | Recruiting | Aug 2028 (est.) | 130 | United States |
| NCT04806620 ClinicalTrials.gov | Unhide® Project: A Digital Health Platform to Collect Lifestyle Data for Brain Inflammation Research | Brain Inflammation Collaborative | Observational | Recruiting | 30 Jun 2030 (est.) | 10,000 | United States |
| NCT06549985 ClinicalTrials.gov | Interdisciplinary Group Care for the Treatment of Endometriosis-associated Pain | Washington University School of Medicine | N/A (non-drug) | Recruiting | 30 Sep 2027 (est.) | 60 | United States |
| NCT06974773 ClinicalTrials.gov | Remote Electrical Stimulation as a Long-term Intervention for Endometriosis Flare Ups | Samphire Group, Inc. | N/A (non-drug) | Recruiting | 1 Jul 2026 (est.) | 120 | United States |
| NCT07127783 ClinicalTrials.gov | Physical Therapy After Endometriosis Excision | Oregon Health and Science University | N/A (non-drug) | Recruiting | Mar 2026 (est.) | 30 | United States |
| NCT05754190 ClinicalTrials.gov | Assessing Symptom and Mood Dynamics in Pain Using the Smartphone Application SOMA | Brown University | Observational | Recruiting | 30 May 2026 (est.) | 800 | United States |
| NCT07144904 ClinicalTrials.gov | Assessing the Efficacy of Indocyanine Green for Ureter Identification During Robot-Assisted Surgery in Advanced-Stage Endometriosis | Baylor College of Medicine | Phase 4 | Not yet recruiting | 1 Feb 2026 (est.) | 40 | United States |
| NCT05739123 ClinicalTrials.gov | Relugolix Pregnancy Registry: An Observational Study of the Safety of Relugolix-Containing Therapy Exposure in Pregnant Women and Their Offspring | Sumitomo Pharma Switzerland GmbH | Observational | Recruiting | May 2033 (est.) | 728 | United States |
| NCT05862272 ClinicalTrials.gov | A Phase 3B Study to Evaluate Bone Mineral Density With Long-Term Use of Relugolix Combination Tablet in Women With Uterine Fibroids or Endometriosis | Sumitomo Pharma Switzerland GmbH | Phase 3 | Recruiting | Jul 2029 (est.) | 1,000 | United States |
| NCT06907550 ClinicalTrials.gov | Mitochondrial DNA Deletions in Plasma as a Diagnostic Aid for Females Presenting With Symptoms of Endometriosis | Pearsanta, Inc | Observational | Not yet recruiting | Apr 2030 (est.) | 1,000 | United States |
| NCT02253251 ClinicalTrials.gov | Clinical Validation of the Role of microRNA Binding Site Mutations in Cancer Risk, Prevention and Treatment | MiraKind | Observational | Recruiting | Dec 2030 (est.) | 15,000 | United States |
| NCT06414083 ClinicalTrials.gov | Histologic Comparison of Ablative Techniques for Endometriosis | TriHealth Inc. | N/A (non-drug) | Recruiting | 9 May 2025 (est.) | 141 | United States |
| NCT05698212 ClinicalTrials.gov | Proof of Concept Study to Eval MetriDx Lab-developed Test to Identify Endometriosis-specific Bio Markers | Hera Biotech, Inc. | Phase 2 | Recruiting | 25 Mar 2023 (est.) | 75 | United States |
Endometriosis trials in other countries: UK · Spain · France · Italy · Netherlands
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Business research data, not medical advice. TrialsForHer summarises public registry records from ClinicalTrials.gov and the EU Clinical Trials Information System (CTIS) for professional and research use. Registry entries can be incomplete or out of date, and dates marked "est." are the sponsor's own estimates. Always check the official record. This isn't a way to enrol in a study; patients and carers should talk to their clinician or the study team listed on the registry.