PCOS · US
PCOS clinical trials in the US (2026)
25 PCOS trials that are recruiting or about to recruit list at least one site in the US: 25 from the US registry (ClinicalTrials.gov) and 0 from the EU registry (CTIS). 2 are industry-sponsored.
By phase
Phase 3: 1, Phase 2: 1, Phase 1: 2, Early Phase 1: 3, N/A (non-drug): 11, Observational: 7
Lead sponsors
University of Virginia (3) · University of California, San Francisco (2) · University of Arkansas, Fayetteville (2) · The Foundation for Orthopaedics and Regenerative Medicine (1) · University of Chicago (1) · The Cleveland Clinic (1)
Open PCOS trials with a site in the US
Newest registry update first. Every ID links to the official record. "est." marks the sponsor's estimated date. A trial registered in both systems may appear twice.
| ID | Title | Lead sponsor | Phase | Status | Primary completion | Enrolment | Site countries |
|---|---|---|---|---|---|---|---|
| NCT06143527 ClinicalTrials.gov | Safety of Cultured Allogeneic Adult Umbilical Cord or Placental Derived Mesenchymal Stem Cells for PCOS | The Foundation for Orthopaedics and Regenerative Medicine | Phase 1 | Recruiting | 16 Nov 2027 (est.) | 20 | Greece, United States |
| NCT07871149 ClinicalTrials.gov | PMOS in OSA Pilot Study | University of Chicago | N/A (non-drug) | Recruiting | Oct 2027 (est.) | 10 | United States |
| NCT07392476 ClinicalTrials.gov | Continuous Glucose Monitoring in Polycystic Ovarian Syndrome | The Cleveland Clinic | Observational | Recruiting | 31 Dec 2026 (est.) | 40 | United States |
| NCT07169136 ClinicalTrials.gov | Effects of Glucagon-like Peptide-1 (GLP-1) Agonist in Neuro-reproductive Function in Obese Adolescent Females With Polycystic Ovary Syndrome (PCOS) | Nemours Children's Clinic | Observational | Recruiting | Dec 2026 (est.) | 20 | United States |
| NCT05819853 ClinicalTrials.gov | Role of Semaglutide in Restoring Ovulation in Youth and Adults With Polycystic Ovary Syndrome | University of Colorado, Denver | Phase 3 | Recruiting | 1 Feb 2028 (est.) | 80 | United States |
| NCT07780188 ClinicalTrials.gov | Lean Beef as Part of a Healthy Meal Plan in Adolescents With Polycystic Ovary Syndrome (PCOS)/Polyendocrine Metabolic Ovarian Syndrome (PMOS) | Texas A&M University | N/A (non-drug) | Recruiting | 30 Apr 2028 (est.) | 36 | United States |
| NCT07727512 ClinicalTrials.gov | PCOS and Brain Health | University of Wisconsin, Madison | Observational | Recruiting | Aug 2028 (est.) | 45 | United States |
| NCT04355572 ClinicalTrials.gov | Evaluation of the Clinical and Psychological Impact of Vitamin D Replacement in Adolescent Females at Risk for Polycystic Ovarian Syndrome (PCOS) | Yale University | N/A (non-drug) | Recruiting | 31 Aug 2028 (est.) | 60 | United States |
| NCT07764328 ClinicalTrials.gov | This Study Aims to Evaluate Whether Milamend's Product Could Improve Hormone Balance in Women Who Suffer From Self-reported PCOS Symptoms. | Mila Mend Inc. | N/A (non-drug) | Recruiting | 27 Oct 2026 (est.) | 225 | United States |
| NCT06852365 ClinicalTrials.gov | Combined Oral Contraceptive Pill and Resistance Starch | University of Pennsylvania | Phase 2 | Recruiting | Apr 2028 (est.) | 100 | United States |
| NCT05979389 ClinicalTrials.gov | Bicalutamide Therapy in Young Women With NAFLD and PCOS | University of California, San Francisco | Phase 1 | Recruiting | Aug 2028 (est.) | 50 | United States |
| NCT07227363 ClinicalTrials.gov | Symptoms of Polycystic Ovarian Syndrome Ameliorated by Keto-Adaptation Pilot | Ohio State University | N/A (non-drug) | Recruiting | Dec 2026 (est.) | 40 | United States |
| NCT05950282 ClinicalTrials.gov | Determinants of Insulin Sensitivity by Age, Sex, Race/Ethnicity, BMI, and PCOS Diagnosis | Ali Chappell | Observational | Recruiting | Oct 2027 (est.) | 150 | United States |
| NCT06124261 ClinicalTrials.gov | Androgens and NAFLD Longitudinal Cohort Study | University of California, San Francisco | Observational | Recruiting | Dec 2028 (est.) | 150 | United States |
| NCT07102797 ClinicalTrials.gov | ActiveGirls: Physical Activity, Hormone Health, and Diabetes Risk in Early Adolescence | Massachusetts General Hospital | N/A (non-drug) | Recruiting | Dec 2027 (est.) | 40 | United States |
| NCT07158723 ClinicalTrials.gov | Protein and Polycystic Ovary Syndrome (PCOS) | University of Arkansas, Fayetteville | N/A (non-drug) | Recruiting | 30 Jun 2027 (est.) | 60 | United States |
| NCT07142603 ClinicalTrials.gov | Appetite Response to Meals With Different Protein Sources in Women With PCOS | University of Arkansas, Fayetteville | N/A (non-drug) | Recruiting | 31 Dec 2026 (est.) | 30 | United States |
| NCT03068910 ClinicalTrials.gov | Hyperandrogenemia and Altered Day-night LH Pulse Patterns | University of Virginia | Early Phase 1 | Recruiting | 1 Oct 2025 (est.) | 32 | United States |
| NCT04723862 ClinicalTrials.gov | Does Spironolactone Normalize Sleep-wake Luteinizing Hormone Pulse Frequency in Pubertal Girls With Hyperandrogenism? | University of Virginia | Early Phase 1 | Recruiting | 1 Oct 2025 (est.) | 32 | United States |
| NCT03401047 ClinicalTrials.gov | Study to Assess Potential Impairments in Estradiol Augmentation of Gonadotropin Secretion in Polycystic Ovary Syndrome | University of Virginia | Early Phase 1 | Recruiting | 1 Oct 2025 (est.) | 37 | United States |
| NCT06049420 ClinicalTrials.gov | Lifestyle Medicine: Establishing Clinical Approaches to Chronic Disease for Rural Patients | West Virginia School of Osteopathic Medicine | N/A (non-drug) | Recruiting | 1 Sep 2027 (est.) | 95 | United States |
| NCT06633120 ClinicalTrials.gov | In Vitro Maturation of Human Eggs | Colorado Center for Reproductive Medicine | N/A (non-drug) | Recruiting | 31 Jul 2029 (est.) | 50 | United States |
| NCT04196595 ClinicalTrials.gov | Apple Women's Health Study | Apple Inc. | Observational | Recruiting | Nov 2029 (est.) | 500,000 | United States |
| NCT05797909 ClinicalTrials.gov | The PCOS Challenge Study | PCOS Challenge: The National Polycystic Ovary Syndrome Association | Observational | Recruiting | Jun 2042 (est.) | 15,000 | United States |
| NCT04149496 ClinicalTrials.gov | IVM With Low Cost Priming, Enhanced Oocyte Recovery, and Delayed Transfer | Bruce Rose, MD | N/A (non-drug) | Recruiting | 1 Apr 2023 (est.) | 300 | United States |
PCOS trials in other countries: France
Other conditions in the US: Endometriosis · Menopause
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Business research data, not medical advice. TrialsForHer summarises public registry records from ClinicalTrials.gov and the EU Clinical Trials Information System (CTIS) for professional and research use. Registry entries can be incomplete or out of date, and dates marked "est." are the sponsor's own estimates. Always check the official record. This isn't a way to enrol in a study; patients and carers should talk to their clinician or the study team listed on the registry.