Menopause · US
Menopause clinical trials in the US (2026)
86 menopause trials that are recruiting or about to recruit list at least one site in the US: 86 from the US registry (ClinicalTrials.gov) and 0 from the EU registry (CTIS). 20 are industry-sponsored.
By phase
Phase 4: 8, Phase 3: 2, Phase 2/3: 1, Phase 2: 7, Phase 1: 3, Early Phase 1: 3, N/A (non-drug): 52, Observational: 10
Lead sponsors
Mayo Clinic (6) · University of Colorado, Denver (4) · University of Missouri-Columbia (3) · University of Minnesota (3) · University of Virginia (2) · Penn State University (2)
Open menopause trials with a site in the US
Newest registry update first. Every ID links to the official record. "est." marks the sponsor's estimated date. A trial registered in both systems may appear twice.
| ID | Title | Lead sponsor | Phase | Status | Primary completion | Enrolment | Site countries |
|---|---|---|---|---|---|---|---|
| NCT07619352 ClinicalTrials.gov | Evaluation of the Effects of Lifestyle Medicine and Mindfulness-based Group Medical Visits on Stress, Microbiome, and Quality of Life in Women Experiencing Perimenopause and Menopause | Ohio State University | N/A (non-drug) | Not yet recruiting | 1 Jan 2028 (est.) | 40 | United States |
| NCT07871396 ClinicalTrials.gov | Exercise Training Intensity and Nitrate Supplementation in Post-Menopausal Females on Hormone Therapy | University of Virginia | N/A (non-drug) | Not yet recruiting | 30 Nov 2027 (est.) | 24 | United States |
| NCT07850050 ClinicalTrials.gov | SYNCHRONIZE®-HERA: A Study to Test Whether Survodutide Helps Women Who Are Living With Overweight or Obesity and Are Going Through or Have Finished Menopause, to Lose Weight | Boehringer Ingelheim | Phase 3 | Not yet recruiting | 26 Jul 2028 (est.) | 600 | United States |
| NCT07042516 ClinicalTrials.gov | Safety and Efficacy of Asimadoline (TP0052) in Patients With Vasomotor Symptoms (VMS). | Tioga Pharmaceuticals | Phase 2 | Recruiting | 31 Oct 2027 (est.) | 120 | United States |
| NCT07861295 ClinicalTrials.gov | Satavari and Ashoka for Menopause (SAM) Study | Vidya USA Corporation | N/A (non-drug) | Recruiting | 1 Dec 2026 (est.) | 50 | United States |
| NCT07218445 ClinicalTrials.gov | The Effect of Tirzepatide on Menopausal Vasomotor Symptoms and Biological Aging in Post-menopausal Women With Obesity | Mayo Clinic | Phase 4 | Recruiting | 18 Sep 2027 (est.) | 40 | United States |
| NCT05440617 ClinicalTrials.gov | Biorepository in Participants Who Undergo OTC for Gonadotoxic Therapy | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | Observational | Recruiting | 21 Sep 2041 (est.) | 100 | United States |
| NCT06798571 ClinicalTrials.gov | Role of Menopause in Thermoregulation | Penn State University | Phase 4 | Recruiting | 1 Dec 2026 (est.) | 24 | United States |
| NCT07848438 ClinicalTrials.gov | Sex Hormones and Aging | University of Michigan | N/A (non-drug) | Recruiting | Aug 2031 (est.) | 120 | United States |
| NCT07688720 ClinicalTrials.gov | Transcutaneous Auricular Neurostimulation (tAN) for Premenstrual Dysphoric Disorder (PMDD) and Perimenopause | Texas Christian University | N/A (non-drug) | Recruiting | Mar 2027 (est.) | 20 | United States |
| NCT07408440 ClinicalTrials.gov | Transdermal Testosterone Gel for Female Sexual Interest and Arousal Disorder in Peri- and Post Menopause | The University of Texas Health Science Center, Houston | N/A (non-drug) | Not yet recruiting | 30 Mar 2028 (est.) | 150 | United States |
| NCT07633743 ClinicalTrials.gov | MenoZen VR for Menopause Symptom Management | Mayo Clinic | N/A (non-drug) | Recruiting | 31 Jul 2027 (est.) | 40 | United States |
| NCT06976112 ClinicalTrials.gov | Impact of Lean Pork on Endothelial Function in Perimenopause | Pennington Biomedical Research Center | N/A (non-drug) | Recruiting | 31 Dec 2026 (est.) | 30 | United States |
| NCT07834463 ClinicalTrials.gov | Randomized Evaluation of Natural Extract for Menopausal Wellness (RENEW) | India Glycols Ltd | N/A (non-drug) | Recruiting | 31 Aug 2027 (est.) | 100 | United States |
| NCT07653620 ClinicalTrials.gov | Hydration & Female Life Stages | PepsiCo Global R&D | N/A (non-drug) | Recruiting | Nov 2026 (est.) | 72 | United States |
| NCT07831499 ClinicalTrials.gov | Cyclic vs. Constant Estradiol: Regimens' Effects on Brain Health | University of Colorado, Denver | Phase 4 | Recruiting | 15 Jul 2028 (est.) | 40 | United States |
| NCT07574216 ClinicalTrials.gov | VEDA Study (DHEA vs Estradiol) | University of Arizona | N/A (non-drug) | Recruiting | 31 Dec 2031 (est.) | 324 | United States |
| NCT07824648 ClinicalTrials.gov | Thermoregulatory Physiology of Menopausal Hot Flashes | SRI International | N/A (non-drug) | Recruiting | 15 Sep 2027 (est.) | 40 | United States |
| NCT07751029 ClinicalTrials.gov | Haelan 951 for Menopause Symptoms in Peri- and Postmenopausal Women | Spectrum Clinical Research, LLC | N/A (non-drug) | Recruiting | Oct 2026 (est.) | 25 | United States |
| NCT07674680 ClinicalTrials.gov | Beta3-adrenergic Receptors and Cardiovascular Function in Aging Women | University of Missouri-Columbia | Early Phase 1 | Recruiting | May 2028 (est.) | 60 | United States |
| NCT06580470 ClinicalTrials.gov | Improving Functioning Among Aging Women Veterans | VA Office of Research and Development | N/A (non-drug) | Not yet recruiting | 1 Dec 2027 (est.) | 48 | United States |
| NCT07794150 ClinicalTrials.gov | A Study to Assess the Skin Irritation and Sensitization of Estradiol/Levonorgestrel TDS in Healthy Postmenopausal Subjects | Corium Innovations, Inc. | Phase 1 | Recruiting | 31 May 2027 (est.) | 250 | India, United States |
| NCT06417177 ClinicalTrials.gov | Impact of Early Aging and Menopause on the Vascular Responses to Hypoxia | University of Missouri-Columbia | Early Phase 1 | Recruiting | Dec 2026 (est.) | 75 | United States |
| NCT06866119 ClinicalTrials.gov | Effects of Estrogen on Heart Health in Women With Primary Ovarian Insufficiency | Massachusetts General Hospital | Observational | Recruiting | 30 Jun 2028 (est.) | 45 | United States |
| NCT07611305 ClinicalTrials.gov | ProGo Menopause Wellbeing Study | Hofseth Biocare ASA | N/A (non-drug) | Not yet recruiting | Dec 2026 (est.) | 100 | United States |
| NCT07242391 ClinicalTrials.gov | Menopausal Hormone Therapy And Left Ventricular Function | Mayo Clinic | Observational | Recruiting | Dec 2027 (est.) | 50 | United States |
| NCT06238700 ClinicalTrials.gov | Study on Allopregnanolone and Depression in Women Across the Menopause Transition | Beth Israel Deaconess Medical Center | N/A (non-drug) | Recruiting | 1 Dec 2027 (est.) | 80 | United States |
| NCT07606664 ClinicalTrials.gov | Fezolinetant and Vascular Health and Brain Health | Rebecca Thurston | Phase 3 | Not yet recruiting | 30 Nov 2029 (est.) | 220 | United States |
| NCT07660315 ClinicalTrials.gov | Goji Berry and Vasomotor Symptoms Pilot Study | University of California, Davis | N/A (non-drug) | Not yet recruiting | 30 Jun 2027 (est.) | 6 | United States |
| NCT07594002 ClinicalTrials.gov | Comparing Acupuncture vs. Sham Acupuncture for the Management of Hot Flashes in Prostate Cancer Patients Receiving Hormone Therapy | University of Kentucky | N/A (non-drug) | Recruiting | 31 Aug 2028 (est.) | 40 | United States |
| NCT06826755 ClinicalTrials.gov | Melatonin Effects on Cardiovascular Disease Mechanisms in Midlife Women: A Randomized Clinical Trial | Mayo Clinic | N/A (non-drug) | Recruiting | Sep 2027 (est.) | 70 | United States |
| NCT07763509 ClinicalTrials.gov | Calcium-Rich Food Versus Calcium Carbonate for Bone Health | Cornell University | N/A (non-drug) | Not yet recruiting | 1 Jun 2027 (est.) | 217 | United States |
| NCT07724522 ClinicalTrials.gov | Prebiotic Inulin for Late-Reproductive Individuals | George Washington University | N/A (non-drug) | Recruiting | Feb 2028 (est.) | 27 | United States |
| NCT06678880 ClinicalTrials.gov | Sleep and Light Intervention (SALI) for Menopausal Mood Dysfunction | University of California, San Diego | N/A (non-drug) | Recruiting | Dec 2028 (est.) | 120 | United States |
| NCT07022340 ClinicalTrials.gov | Hemodynamics After Resistance Training | University of Michigan | N/A (non-drug) | Recruiting | Dec 2026 (est.) | 50 | United States |
| NCT07705724 ClinicalTrials.gov | Effect Of Whole or Skimmed Milk Greek Yogurt on Integrated Muscle Protein Synthesis, Glucose Homeostasis, and Cognition in Post-Menopausal Women | University of Arkansas | N/A (non-drug) | Not yet recruiting | 1 Oct 2028 (est.) | 40 | United States |
| NCT07526948 ClinicalTrials.gov | Vaginal Estradiol vs Moisturizer to Improve Postmenopausal Vaginal Aging Symptoms and the Microbiome in Women Living With HIV | Albert Einstein College of Medicine | Phase 4 | Not yet recruiting | 30 Sep 2029 (est.) | 62 | United States |
| NCT07365514 ClinicalTrials.gov | Blackcurrants Modify Gut Microbiota and Reduce Osteoporosis Risk in Postmenopausal Females | University of Connecticut | Phase 1 | Recruiting | Feb 2028 (est.) | 159 | United States |
| NCT06673004 ClinicalTrials.gov | Ovarian Tissue Allo-transplantation | University Hospitals Cleveland Medical Center | N/A (non-drug) | Not yet recruiting | 30 May 2030 (est.) | 10 | United States |
| NCT06975111 ClinicalTrials.gov | Focusing on the Menopausal Transition to Improve Mid-Life Women's Health | University of Colorado, Denver | Phase 2/3 | Recruiting | 31 Oct 2029 (est.) | 200 | United States |
| NCT06480695 ClinicalTrials.gov | Exercise Training Intensity and Nitrate Supplementation in Post-Menopausal Females | University of Virginia | N/A (non-drug) | Recruiting | 31 Dec 2026 (est.) | 40 | United States |
| NCT06743269 ClinicalTrials.gov | Time-Efficient Inspiratory Muscle Strength Training for Reducing Sympathetic Activity and Improving Sleep in Midlife Women | Mayo Clinic | N/A (non-drug) | Recruiting | 1 Jan 2027 (est.) | 30 | United States |
| NCT07679074 ClinicalTrials.gov | CREST: Samphire Guided Care Program on Wellbeing, Work Productivity, and Quality of Life | Samphire Group, Inc. | Observational | Recruiting | 1 Jan 2027 (est.) | 50 | United States |
| NCT07678359 ClinicalTrials.gov | Effect of ZenRest™ Lotus Seed & Rice Germ Extract Blend on Sleep Quality in Menopausal Women | Nutraland USA, Inc. | N/A (non-drug) | Not yet recruiting | Sep 2026 (est.) | 60 | United States |
| NCT07427459 ClinicalTrials.gov | Amygdala Insula Retraining in the Management of Perimenopause Symptoms | Chronic Conditions Research Fund | N/A (non-drug) | Recruiting | 31 Jan 2027 (est.) | 160 | United States |
| NCT07314827 ClinicalTrials.gov | Women's Healthy Aging and Menopause; (WHAM) | University of Miami | N/A (non-drug) | Not yet recruiting | 31 Jan 2028 (est.) | 60 | United States |
| NCT07158021 ClinicalTrials.gov | Leuprolide and Goserelin for Ovarian Function Suppression in Pre- or Peri-menopausal Women With Breast Cancer, OFS Trial | University of Michigan Rogel Cancer Center | Phase 2 | Recruiting | 1 Jan 2028 (est.) | 75 | United States |
| NCT05193968 ClinicalTrials.gov | Hot Flashes and Neurovascular Function in Women | Mayo Clinic | N/A (non-drug) | Recruiting | Dec 2026 (est.) | 120 | United States |
| NCT07635017 ClinicalTrials.gov | Assessing the Effects of Hormones on Noninvasive Transcranial Stimulation | Carnegie Mellon University | N/A (non-drug) | Not yet recruiting | 1 May 2028 (est.) | 25 | United States |
| NCT07136415 ClinicalTrials.gov | Comparing Digital Therapy, Trazodone, and Daridorexant for Menopause-Related Insomnia Symptoms | Brigham and Women's Hospital | Phase 4 | Recruiting | Feb 2031 (est.) | 1,000 | United States |
| NCT06917313 ClinicalTrials.gov | FLASH-Breast: Evaluating the Efficacy of Fezolinetant in Reducing Vasomotor Symptoms in Women With Breast Cancer on Endocrine Therapy | Yale University | Phase 2 | Recruiting | Mar 2028 (est.) | 92 | United States |
| NCT06856174 ClinicalTrials.gov | Menopausal HT for Women Living With HIV (HoT) | Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections | Phase 4 | Recruiting | 20 Sep 2027 (est.) | 105 | United States |
| NCT06490146 ClinicalTrials.gov | Menopause Transition, Sex Hormone Deficiency and Autonomic and Vascular Function | University of Minnesota | Observational | Recruiting | 21 Aug 2030 (est.) | 100 | United States |
| NCT07077395 ClinicalTrials.gov | Finding Links Between Hot flASHes and CardioVascular Disease | Massachusetts General Hospital | Phase 2 | Recruiting | Jun 2029 (est.) | 80 | United States |
| NCT06982677 ClinicalTrials.gov | Improving Outcomes in Early Menopause After Cancer | Duke University | N/A (non-drug) | Recruiting | May 2027 (est.) | 117 | United States |
| NCT05251324 ClinicalTrials.gov | The Cardiovascular Impact of Hot Flushes | University of Minnesota | Observational | Recruiting | 26 May 2027 (est.) | 60 | United States |
| NCT07570732 ClinicalTrials.gov | Occupational Disruption and Role Strain During Perimenopause | Russell Sage College | Observational | Not yet recruiting | 1 Dec 2026 (est.) | 100 | United States |
| NCT07284082 ClinicalTrials.gov | The Synergistic Effects of Menopause and HIV on Cardiovascular Disease Risk in Women | University of California, San Francisco | Observational | Recruiting | 1 Mar 2030 (est.) | 90 | United States |
| NCT07402382 ClinicalTrials.gov | Effects of Amylopectin Chromium Blend on Whole-Body Protein Kinetics and Glucose in Peri/Post-Menopausal Women | Nutrition 21, Inc. | N/A (non-drug) | Recruiting | 30 Jun 2026 (est.) | 60 | United States |
| NCT07393672 ClinicalTrials.gov | Effects of Hemp-Derived Cannabinoids on Menopause Symptoms | Washington State University | Phase 2 | Recruiting | 10 Nov 2026 (est.) | 104 | United States |
| NCT01530373 ClinicalTrials.gov | Solifenacin Compared to Clonidine for Reducing Hot Flashes Among Breast Cancer Patients | University of Arkansas | Phase 2 | Recruiting | Jul 2027 (est.) | 110 | United States |
| NCT07441109 ClinicalTrials.gov | Shatavari Root Extract for Perimenopausal Symptoms | SF Research Institute, Inc. | N/A (non-drug) | Not yet recruiting | 15 Jun 2026 (est.) | 60 | United States |
| NCT05672901 ClinicalTrials.gov | Silicone Gel vs. Estrogen Vaginal Cream for the Management of Genitourinary Syndrome of Menopause | Stratpharma AG | N/A (non-drug) | Recruiting | Sep 2026 (est.) | 100 | United States |
| NCT05953090 ClinicalTrials.gov | VALOR: Vaginal Atrophy & Long-term Observation of Recovery | Stratpharma AG | N/A (non-drug) | Recruiting | Jun 2028 (est.) | 2,000 | United States |
| NCT06691178 ClinicalTrials.gov | Vaginal Changes After CO2 Laser | University of California, Irvine | N/A (non-drug) | Recruiting | 1 May 2027 (est.) | 50 | United States |
| NCT07413705 ClinicalTrials.gov | BTL-699-2 and HPM-6000UF Devices for the Improvement of Depressive Symptoms and Sexual Function Among Perimenopausal and Postmenopausal Women | BTL Industries Ltd. | N/A (non-drug) | Recruiting | 11 Dec 2026 (est.) | 60 | Canada, United States |
| NCT06965686 ClinicalTrials.gov | Development of a Personalized, Psychosocial Intervention for Menopausal Individuals With Elevated Dementia Risk | University of Chicago | N/A (non-drug) | Recruiting | 30 Dec 2026 (est.) | 60 | United States |
| NCT07120997 ClinicalTrials.gov | Prunes Preventing Bone Loss in Perimenopause | Penn State University | N/A (non-drug) | Recruiting | Sep 2029 (est.) | 124 | United States |
| NCT07356479 ClinicalTrials.gov | Enhancing Mental and Physical Health of Women Veterans 3.0 | VA Office of Research and Development | N/A (non-drug) | Not yet recruiting | 30 Sep 2030 (est.) | 18 | United States |
| NCT07342400 ClinicalTrials.gov | A Clinical Study to Assess Histological Changes From Treatment of Poly L-lactic Acid Biostimulator on Women at Various Menopausal Stages | Galderma R&D | N/A (non-drug) | Recruiting | Nov 2026 (est.) | 40 | United States |
| NCT04439370 ClinicalTrials.gov | Autonomic Regulation of Blood Pressure in Premature and Early Menopausal Women | University of Minnesota | Observational | Recruiting | 30 Dec 2026 (est.) | 160 | United States |
| NCT06376812 ClinicalTrials.gov | No Time to Pause: Physical Activity to Improve Health of Midlife Hispanic Women | The University of Texas Medical Branch, Galveston | N/A (non-drug) | Not yet recruiting | Jan 2029 (est.) | 40 | United States |
| NCT07238478 ClinicalTrials.gov | JDS-HF3.0 Supplementation on Menopause Related Quality of Life Outcomes in Postmenopausal Women | Bonafide Health | N/A (non-drug) | Recruiting | Jul 2026 (est.) | 250 | United States |
| NCT07210229 ClinicalTrials.gov | The Effectiveness of a Proprietary Ashwagandha Extract on Menopausal Symptoms: A Three-Arm Randomized, Double-Blinded, Placebo Controlled Clinical Trial | Nutraceuticals Research Institute | N/A (non-drug) | Not yet recruiting | 28 Feb 2026 (est.) | 90 | United States |
| NCT06787066 ClinicalTrials.gov | Sympathetic Vascular Transduction Across the Menopause Transition: Contributing Mechanisms | University of Missouri-Columbia | Early Phase 1 | Recruiting | Dec 2026 (est.) | 75 | United States |
| NCT07146321 ClinicalTrials.gov | A Study to Investigate the Effect of a Multivitamin, Multi-nutrient Supplement on Mental and Emotional Wellbeing | Biologica Inc | N/A (non-drug) | Not yet recruiting | 9 Mar 2026 (est.) | 80 | United States |
| NCT07033013 ClinicalTrials.gov | A Randomized, Double Blind, Placebo Controlled, Clinical Study to Examine the Benefits of an Oral Product in Panelists With Menopausal Symptoms Including Vasomotor Symptoms (VMS). | Olly, PBC | N/A (non-drug) | Recruiting | 25 Jul 2025 (est.) | 40 | United States |
| NCT06644573 ClinicalTrials.gov | Evaluating the Efficacy and Safety of PROSOMNIA Sleep Therapy™ in Patients With Sleep Deprivation and Chronic Insomnia | Nyree Penn | Phase 1 | Not yet recruiting | 1 May 2026 (est.) | 100 | United States |
| NCT06939868 ClinicalTrials.gov | Effect of a Cepham Supplement on Hot Flashes and Menopausal Symptoms in Postmenopausal Women | Jacksonville University | N/A (non-drug) | Not yet recruiting | 30 Aug 2025 (est.) | 44 | United States |
| NCT06798584 ClinicalTrials.gov | How Does Perimenopausal Menorrhagia Affect Women's Quality of Life and Cognitive Function? | Purdue University | N/A (non-drug) | Not yet recruiting | Dec 2025 (est.) | 240 | United States |
| NCT06768073 ClinicalTrials.gov | Intravaginal Negative Pressure Medical Device for Treatment of Genitourinary Syndrome of Menopause (GSM) | AVeta Medical | N/A (non-drug) | Not yet recruiting | 3 Nov 2025 (est.) | 60 | Georgia, United States |
| NCT06716554 ClinicalTrials.gov | Efficacy and Safety of Shatavari for Treatment of Menopausal Symptoms in Women: A Randomized, Double-blind, Three-arm, Parallel, Placebo-controlled Study | SF Research Institute, Inc. | N/A (non-drug) | Recruiting | 26 Dec 2024 (est.) | 51 | United States |
| NCT06082817 ClinicalTrials.gov | An Open-Label Study of 50 Mg Oral Testosterone Undecanoate (Kyztrex) in Menopausal Women with Low Testosterone and HSDD | San Diego Sexual Medicine | Phase 2 | Not yet recruiting | 31 Dec 2025 (est.) | 30 | United States |
| NCT04196595 ClinicalTrials.gov | Apple Women's Health Study | Apple Inc. | Observational | Recruiting | Nov 2029 (est.) | 500,000 | United States |
| NCT06264882 ClinicalTrials.gov | Cardiometabolic Consequences of the Loss of Ovarian Function | University of Colorado, Denver | Phase 4 | Recruiting | 31 May 2028 (est.) | 100 | United States |
| NCT04043520 ClinicalTrials.gov | Bioenergetic Effects of Aging and Menopause (BEAM) | University of Colorado, Denver | Phase 4 | Recruiting | 31 Aug 2024 (est.) | 57 | United States |
Menopause trials in other countries: UK · Spain · France · Italy
Other conditions in the US: Endometriosis · PCOS
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Business research data, not medical advice. TrialsForHer summarises public registry records from ClinicalTrials.gov and the EU Clinical Trials Information System (CTIS) for professional and research use. Registry entries can be incomplete or out of date, and dates marked "est." are the sponsor's own estimates. Always check the official record. This isn't a way to enrol in a study; patients and carers should talk to their clinician or the study team listed on the registry.